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Polymorphism in the pharmaceutical industry by Rolf Hilfiker

Polymorphism in the pharmaceutical industry Rolf Hilfiker ebook
Format: pdf
ISBN: 3527311467, 9783527311460
Page: 433
Publisher: Wiley-VCH

One third of phar- maceutical drugs are estimated to be polymorphic, and this. Applied catalysis, which is directed at developing novel catalysts and processes relevant to the petrochemical, fine chemical and pharmaceutical industries 2. Polymorphism – is your pharmaceutical company in good shape? Every year, the pharmaceutical industry invests billions of dollars in testing drugs that are eventually abandoned because they don't work or cause side effects. What if scientists could make better use of technology to predict which drugs will work and pinpoint Now you need to know something about genetic polymorphisms (gene variants) that each individual may carry. He points out that pioneer companies, those who first create the pharmaceutical product widely claim that patent claims for novel crystal forms is an important component of their intellectual property position, but that it significantly delays the entry of generic versions of drugs once “There are numerous instances where innovator companies have acquired patents on a particular polymorphic form,” says Vure, “which extend beyond the expiry of basic molecule's patent. The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Comprehensive reference for researchers in the field of cancer pharmacogenomics and clinicians, from both academia and industry; Provides a collection of multi-disciplinary topics; Covers the most important aspects of pharmacogenomics applied to cancer patients. All you want to know about Drugs, live, by DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Helping millions, million hits on google, pushing boundaries, one lakh connections worldwide, my soul in action for you .. Over the last twenty years, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug These efforts are made in order to avoid latestage drug failure due to such factors as undesirable metabolic instability, toxic metabolites, drug-drug interactions, or polymorphic and saturation metabolism. Q: Is genomic sequencing also part of the picture? The ability to isolate, dif- ferentiate, and characterize individual polymorphs is a major challenge to the pharmaceutical industry. And salt used, pH, and temperature.